What is CFTS?
Combined First Trimester Screening (CFTS) is a safe, non-invasive test performed between 11 and 13 weeks of pregnancy. It helps estimate your baby’s risk for common chromosomal conditions such as Down syndrome (Trisomy 21), Trisomy 18, and Trisomy 13 by combining ultrasound measurements with a simple blood test.
Why is it done?
- To provide early information about your baby’s health
- Recommended if you are age 35 or older at delivery
- Advised if there is a family history of chromosomal disorders
- If earlier screening tests or ultrasound findings raise concerns
When should I get tested?
The ideal testing window is between 11 weeks and 13 weeks + 6 days of pregnancy. Scheduling outside this period may affect accuracy.
How is it performed?
- You will have an ultrasound to measure the fluid at the back of your baby’s neck (nuchal translucency)
- A small sample of your blood is drawn to measure two proteins: PAPP-A and free β-hCG
- The ultrasound and blood results are entered into specialized software to calculate your personalized risk
Benefits and Limitations
Benefits:
- Non-invasive with no risk to you or your baby
- Early risk assessment (detection rate ~85–90% for Down syndrome)
Limitations:
- Not diagnostic – it indicates risk; positive results need confirmation
- False-positive rate around 5%
- May be less accurate in twins or high body mass index
Frequently Asked Questions (FAQs)
Is the test safe for my baby?
Yes. CFTS uses ultrasound and a maternal blood sample; there is no risk to the fetus.
What happens if my result is high risk?
A high-risk result means your baby may have a chromosomal condition. We recommend diagnostic testing (CVS or amniocentesis) for confirmation.
Do I need to fast before the blood test?
No fasting is required; you can eat and drink normally.
How long will I wait for results?
Results are typically available within 5–7 business days.
Will insurance cover this test?
Coverage varies. Please check with your insurance provider for details.
Can I choose cell-free DNA testing instead?
Yes. Discuss with your doctor if you prefer cfDNA testing; it may offer higher accuracy but at higher cost.